Inhibitors | Comment | Organism | Structure |
---|---|---|---|
8-Azaguanine | 43% inhibition at 2.9 mM | Escherichia coli | |
8-ethoxycarbonyl-7-deazaguanine | 78% inhibition at 2.9 mM | Escherichia coli | |
8-methyl-7-deazaguanine | 94% inhibition at 2.9 mM | Escherichia coli | |
8-trifluoromethyl-7-deazaguanine | 17% inhibition at 2.9 mM | Escherichia coli | |
additional information | synthesis and inhibitory potential of 7-deazaguanine derivatives on GTPCH I, inhibitory mechanism, overview | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Escherichia coli | first step in the biosynthesis pathway leading to dihydrofolate and tetrahydrobiopterin | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Escherichia coli | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? | |
GTP + H2O | first step in the biosynthesis pathway leading to dihydrofolate and tetrahydrobiopterin | Escherichia coli | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GTPCH I | - |
Escherichia coli |
guanosine triphosphate cyclohydrolase I | - |
Escherichia coli |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
26 | - |
assay at | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
assay at | Escherichia coli |